The Biological Function and Molecular Mechanism of Ampelopsin and Exercise Mimetics in Chronic DiseasesContentsChapter 1Pharmacological potential of ampelopsin in Rattan tea1
Chapter 2Ampelopsin reduces endotoxic inflammation via repressing ROSmediated
activation of PI3KAktNFB signaling pathways8
Chapter 3Natural products for cancer prevention associated with Nrf2ARE pathway23
Chapter 4Antitumor effect31
4.1Potential molecular targets of ampelopsin in prevention and treatment of
cancers31
4.2Nutraceutical or pharmacological potential of Moringa oleifera Lam.39
4.3Ampelopsin induces apoptosis in HepG2 human hepatoma cell line through
extrinsic and intrinsic pathways：involvement of p38 and ERK48
Chapter 5Neuroprotective effect59
5.1Ampelopsin inhibits H2O2induced apoptosis by ERK and Akt signaling
pathways and upregulation of heme oxygenase159
5.2Ampelopsin attenuates 6OHDAinduced neurotoxicity by regulating
GSK3NRF2ARE signaling67
Chapter 6Autophagy and brain aging77
6.1Autophagy as the modulator of neuronal homeostasis and neurodegenerative disorders77
6.2Resveratrol as a natural autophagy regulator for prevention and treatment of Alzheimers disease80
6.3Ampelopsin attenuates brain aging of Dgalinduced rats through miR34amediated SIRT1mTOR signaling pathway89
6.4Swimming attenuates Dgalactoseinduced brain aging via suppressing miR34amediated autophagy impairment and abnormal mitochondrial dynamics101
6.5Voluntary wheel running exercise suppresses brain aging of rats through activating miR130amediated autophagy112
Chapter 7Sarcopenia123
7.1Research progress of sarcopenia123
7.2MicroRNAregulated proinflammatory cytokines in sarcopenia127
7.3Ampelopsin attenuates Dgalinduced oxidative stressrelated skeletal muscle atrophy through activating AMPKSIRT1PGC1 signaling cascade135
7.4Role and regulation of autophagy in mass maintenance of skeletal muscle147
Acknowledgement155
References156
內容試閱：
Ampelopsis grossedentata is widely distributed in the South of China.Its tender stems and leaves are exploited in China to prepare a health beverage named as Rattan tea.Ampelopsin is one of the most important flavonoids found in Rattan tea.As a dihydromyricetin DHM，ampelopsin was first isolated from Ampelopsis meliaefolia by Kotake and Kubota in 1940，and was reported as a major bioactive component in Ampelopsis grossedentata later.Nowadays，ampelopsin，as a major bioactive component in Rattan tea，has a broad range of biological functions.During the past decade，the bioactivity of ampelopsin in Rattan tea has gained extensive attention and increasing scientific investigations related to its pharmacological functions and underlying mechanisms have been reported.Herein，the current research progress in the pharmacological functions and corresponding action mechanisms as well as potential benefits in chronic diseases have been summarized.This study will start a series of studies of ampelopsin from the following aspects：antiinflammatory，antioxidative，antitumor and neuroprotective effects，and alleviate brain aging and sarcopenia.We mainly focus the effect and molecular mechanism of ampelopsin on inflammation，tumor and neuroprotective effects in different cells and animal models.
Many intervention strategies have been investigated in order to understand their ability for slowing down the aging process of brain and skeletal muscle，and exercise training has been confirmed to inhibit oxidative stress and apoptotic signaling，thus effectively executing neuroprotection and sarcopenia.Aerobic exercise，such as running，has been proven to be a very effective way to improve adult hippocampal neurogenesis and learning.Some reports have also shown that treadmill and voluntary wheel running can improve behavioral performance and accelerate mitochondrial fitness of brain by reducing oxidative damage，rescuing abnormal mitochondrial dynamics，and inhibiting excessive apoptotic signaling.
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